FACTORS AFFECTING TRAIN-OF-FOUR FADE

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Factors affecting train-of-four fade.

The characteristics of the train-of-four response during neuromuscular blockade with two agents, atracurium and vecuronium, have been compared. During onset of blockade, at 75% depression of the initial twitch, atracurium was associated with significantly more fade than was vecuronium, and larger doses of atracurium were associated with less fade than smaller doses of the same agent. In additio...

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Nondepolarizing neuromuscular blocking drugs and train-of-four fade.

The aim of this study was to examine differences in prejunctional effects of different relaxants by measuring the train-of-four (TOF) fade during the onset and recovery of neuromuscular block. The relaxants studied were atracurium (225 micrograms.kg-1), mivacurium (65 micrograms.kg-1) rocuronium (300 micrograms.kg-1) and vecuronium (40 micrograms.kg-1). The TOF ratios were measured at approxima...

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Analysis of Factors Affecting Train Derailments

22 23 Implementation of highway-rail grade crossing warning systems, educational programs and 24 research on crossings have all contributed to a steady reduction in the risk to highway users of 25 grade crossings over the past several decades. Much less attention has been given to 26 understanding the effect of grade crossings on train safety and risk. Collisions at highway-rail 27 grade crossi...

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Comparison of the train-of-four fade profiles produced by vecuronium and atracurium.

In this double-blind study, we have allocated randomly 40 ASA I-III patients to one of four groups. After a standard anaesthetic induction, patients received vecuronium 0.08 mg kg-1 or 0.10 mg kg-1, or atracurium 0.4 mg kg-1 or 0.5 mg kg-1. Using an electromyogram (Datex Relaxograph) the train-of-four (TOF) response was measured during onset of and recovery from neuromuscular block. A greater d...

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Block of postjunctional muscle-type acetylcholine receptors in vivo causes train-of-four fade in mice.

BACKGROUND Train-of-four (TOF) fade during nerve-mediated muscle contraction is postulated to be attributable to inhibition of prejunctional nicotinic α3β2 acetylcholine receptors (nAChRs), while decrease of twitch tension is attributable to block of postjunctional muscle nAChRs. The validity of these presumptions was tested using specific prejunctional and postjunctional nAChR antagonists, tes...

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ژورنال

عنوان ژورنال: British Journal of Anaesthesia

سال: 1985

ISSN: 0007-0912

DOI: 10.1093/bja/57.6.602